“These 10 cutting-edge projects highlight the impressive diversity of health research at UM,” said Dr. Peter Nickerson, dean of the Rady Faculty of Health Sciences.

“Some are lab studies that will advance knowledge of conditions like heart disease and cancer. Two projects focus on Indigenous health. Three studies are randomized controlled trials to be conducted at hospitals, with the potential to influence treatment protocols in the areas of kidney transplant rejection, pneumonia and stroke.”      

Dr. Christine Kelly, an associate professor in the College of Community and Global Health with expertise in home care and the care workforce, received nearly $1 million for a four-year study.

She and her team aim to learn more about the lives of health-care aides (HCAs) in Manitoba. The goal is to uncover why so many leave the field, and what can be done to recruit, support and retain these employees who do essential work in home-care programs and personal care homes.

“Research shows that as many as 40 per cent of recently graduated HCAs will leave their job within the first year of employment,” Kelly said. “The period during and immediately following training is a key time for understanding what is happening with these workers, who are mostly women and are often new Canadians.”

All five public colleges that train HCAs in Manitoba – RRC Polytech, Assiniboine Community College, Université de Saint-Boniface, Manitoba Institute of Trades and Technology and University College of the North – will be involved in the provincewide study, titled “Care workers of tomorrow: Health-care aide experiences and education-to-work pathways to support retention and workforce planning.”

The project will follow HCAs from the start of their training and into their first year of employment, documenting why they stay at or leave their jobs. Based on the findings, Kelly’s team will make recommendations for educational institutions, policy-makers and employers.

Here are the other UM recipients of CIHR grants in the Spring 2025 round of funding: 

Dr. Michael Czubryt, professor of physiology and pathophysiology; executive director of research, St. Boniface Hospital

Grant: $1,149,414 (five years)

Czubryt will investigate how a protein, scleraxis, controls the conversion of heart cells called fibroblasts into myofibroblasts – a process that drives cardiac fibrosis, or stiffening of the heart, in cardiac disease. With greater insight into the role played by this protein, Czubryt’s team aims to help identify new targets for anti-fibrosis drug development.

Dr. Julie Ho, professor of internal medicine

Grant: $2,757,826 (five years)

Ho’s team will lead an international, multi-centre, randomized controlled trial to define the optimal steroid therapy for T-cell mediated rejection (TCMR) of kidneys after transplant. This trial aims to resolve the longstanding question, “What is the minimally acceptable, safe and effective steroid dose for the treatment of acute TCMR in kidney and simultaneous kidney pancreas transplant recipients?”

Dr. Jennifer Kornelsen, associate professor of radiology

Grant: $623,476 (five years)

Seeking to understand depression and anxiety in people with inflammatory bowel disease (IBD), Kornelsen will use magnetic resonance imaging to investigate the brain and spinal cord activity of patients who have IBD with depression/anxiety; those who have IBD without those conditions; and healthy people. The study will also test how the spinal cord carries information between the brain and the gut in IBD.

Dr. Sylvain Lother, assistant professor of internal medicine

Grant: $180,000 (three years)

Lother is leading a pilot randomized controlled trial of 120 patients across Canada in preparation for a much larger trial involving thousands of patients with community-acquired pneumonia. The goal is to establish whether one antibiotic strategy is better than others for certain groups of patients hospitalized with pneumonia.

Dr. Jonathan McGavock, professor of pediatrics and child health

Grant: $100,000 (one year)

McGavock’s project continues his research on how urban trails in Canadian cities rarely reach or serve the needs of urban-dwelling Indigenous people. This study will provide evidence-based policy and practice recommendations co-created with First Nations families and Elders/Knowledge Keepers for how to implement urban trails in an equitable way for First Nations people.

Dr. Kirk McManus, professor of biochemistry and medical genetics

Grant: $1,208,700 (five years)

McManus’s project will use cutting-edge techniques to study the expression of a gene, SKP2, that appears to play a role in the development of tubo-ovarian high-grade serous carcinoma, the most common and lethal form of ovarian cancer. The team hopes to gain knowledge that will lead to new therapeutic options for people with this cancer.

Dr. Claudio Rigatto, professor of internal medicine

Grant: $765,000 (three years)

Rigatto’s team will develop a small, easy-to-use, low-cost test for rapid, accurate assessment of kidney function in settings such as clinics, pharmacies, schools, and potentially homes. The test will use a new method for measuring kidney function, called cystatin C. The team aims to make kidney testing as widely available as possible to improve access to chronic kidney disease diagnosis.

Dr. Leslie E. Roos, associate professor of psychology

Grant: $489,600 (three years)

Roos’s team has developed an app-based mental health and parenting support program called BEAM (Building Emotional Awareness and Mental Wellbeing). In this project, the team is working with Indigenous researchers, Elders, community members and organizations to build, test and evaluate a cultural adaptation of BEAM that meets the expressed needs of Indigenous families.  

Dr. Nishita Singh, assistant professor of internal medicine; Heart & Stroke & Research Manitoba Chair in Clinical Stroke Research

Grant: $768,826 (three years)

Singh’s study aims to determine whether it’s safe for patients who take blood thinners called direct oral anticoagulants (DOACs) to receive a clot-busting medication (tenecteplase) when they are having an ischemic stroke. Currently, guidelines say patients who are on DOACs should not be given clot-busting medication. This randomized controlled trial will test different doses of tenecteplase.

The Emerging Scholar Podcast features host and producer Dr. Jonathan McGavock, a professor of pediatrics and child health at the Max Rady College of Medicine, speaking with a variety of experts in the health sciences research field. The Podcast is produced and supported by UMFM with the help of co-producer Jared McKetiak.

 McGavock, also a researcher with the Children’s Hospital Research Institute of Manitoba, says each episode is a conversation that will take students through the scientific process of generating ideas, testing a clinical hypothesis and sharing the results.  

“The amount of information available to residents getting started in research is enormous and could be super intimidating. We are providing a starting point and map to simplify the process,” said McGavock. 

The first two episodes focus on ‘how to develop a research question’ with episode one featuring a dialogue with pioneering pediatric researcher and professor Dr. Peter Rosenbaum of McMaster University.  Other early episodes give insights into topics like choosing a mentor, an introduction to various types of clinical research designs and incorporating race and anti-racism into a research project. 

McGavock said this podcast will also provide residents with a set of tools and resources they can easily access when they are working on their own (here). Since each episode is only 30 minutes, it allows those with limited time an opportunity to listen while on their commute or during other daily activities. 

“Every episode has a guest scientist in a different domain and should help fast-track the learner’s project. They will benefit from this interplay of discussion and Q & A with an expert, and then they can go right to the resource that they need, so they can do this independently.” 

While the podcast is geared towards residents, McGavock said graduate students and scientists at every level could also benefit from it. 

“Any graduate student launching into a project that involves humans could enjoy and learn from these interviews. There’s a big pool of students wanting to get into clinical research and I think they can use this as an entry level resource and learn what is expected at the highest level.”  

McGavock has three seasons of the podcast mapped out, as that is the typical length for a residency research project, but said he has no plans to stop making new episodes once the three seasons are complete.  

“This podcast has been a dream of mine for years and without the incredible support and production from UMFM station manager Jared McKetiak it would not be possible,” said McGavock. The first of 14 episodes was released in early 2025 and will drop weekly until mid April.  Episodes can be found on all streaming platforms along with the companion website and UMFM website.  

“Congratulations to the UM researchers who secured CIHR funding for their cutting-edge work in health and well-being,” said Dr. Mario Pinto, UM vice-president, research and international. “This recognition highlights the impact of UM’s innovative health research. These researchers are driving solutions for better health care in Manitoba and globally.” 

Dr. Peter Nickerson, vice-provost (health sciences) and dean of the Rady Faculty of Health Sciences, said the funded projects show the diversity of health research taking place across UM ranging from investigating gut health and HIV/HPV progression to reducing inequities in trail use for urban First Nation and Métis people and examining the interaction of dietary flaxseed with blood pressure medication. 

“The researchers who received project funding are from eight different Max Rady College of Medicine departments, the College of Pharmacy, the Faculty of Education and the Faculty of Agricultural and Food Sciences,” Nickerson said. “CIHR funding is vital to the research that takes place at UM. And it’s essential in advancing science with provincial, national and global implications.”  

One of the 12 grant recipients is Dr. Inna Rabinovich-Nikitin, assistant professor of physiology and pathophysiology at the Max Rady College of Medicine. She and her team received $1,032,750 over five years to study what could one day lead to new treatments to reduce the risk of heart disease in people with disrupted circadian rhythms.  

Circadian rhythms are 24-hour cycles that regulate changes in the body, including heart rate and blood pressure. When the circadian rhythm is disrupted by things like shift work, poor sleep or jet lag, it has a negative impact on the heart and could lead to heart disease, Rabinovich-Nikitin said.  

“It’s known that shift workers have a 40 per cent higher risk of heart attacks, but we can’t do without shift work, so our research is working to develop treatments to help people with disrupted circadian rhythm, such as shift workers,” said Rabinovich-Nikitin, who is also a researcher with the Institute of Cardiovascular Sciences, a joint St. Boniface Hospital Research and UM institute.  

Rabinovich-Nikitin’s preliminary studies suggest that a disrupted circadian rhythm results in abnormal lipid metabolism and accumulation of lipids in the heart, and this might be the underlying cause of heart failure following a heart attack.  

“The goal of the newly funded project is to determine how circadian genes affect lipid metabolism following a heart attack and to understand how modulation of circadian proteins can improve lipid metabolism and cardiac function following a heart attack,” she said.   

“We know how diet and exercise contribute to one’s health, but circadian rhythm is a neglected area of research. It’s very important to have a normal circadian rhythm, and we’re working hard to better understand its impact on our health.”     

UM CIHR project funding recipients 

Dr. Michel Aliani, professor of food and human nutritional sciences, Faculty of Agricultural and Food Sciences; principal investigator, nutritional metabolomics research, division of neurodegenerative disorders, St. Boniface Hospital Albrechtsen Research Centre 

Project: The capacity for dietary flaxseed to inhibit the metabolism of antihypertensive drugs 

Grant: $1,189,575 (five years) 

Using state-of-the-art instrumentation, Aliani’s study aims to prove that flaxseed ingested in the diet can interact with drugs that control blood pressure. Data from the study will explain the action of dietary flaxseed in lowering blood pressure and provide important safety data on the interaction of flaxseed in one’s diet with drugs that lower blood pressure.  

Dr. Marissa Becker, professor of community health sciences, Max Rady College of Medicine, Rady Faculty of Health Sciences; director of technical collaborations at the Institute for Global Public Health 

Project: Prioritizing Place in Sexually Transmitted and Blood-Borne Infection prevention in Kenya: Reframing prevention programs through Program Science 

Grant: $975,375 (five years) 

Using a program science approach, Becker and the team will develop a deeper understanding of how physical, organizational, social and relational dimensions of “place” shape ecologies of risk and safety for prioritized adolescent girls and young women (15-24 years), female sex workers and their male sexual partners in Nairobi County, Kenya. This work will generate contextualized knowledge for prioritizing place-based strategies to optimize sexually transmitted and blood-borne infection prevention program coverage and address unmet needs.  

Dr. Lucy Delgado, assistant professor of educational administration, foundations and psychology, Faculty of Education 

Project: The impact of Métis-specific spaces on the health and wellness of Métis women and Two-Spirit/Indigiqueer people 

Grant: $1,017,452 (four years)  

Through data collected as part of a series of gatherings, interviews and qualitative surveys, Delgado’s project will measure the outcomes for Métis women and Two-Spirit/Indigiqueer peoples engaged in Métis-specific spaces and provide a framework for post-secondary institutions in their creation of Métis-specific spaces. The final stage of this project will be an evaluation of the efficacy of the framework when taken up by new institutions. 

Dr. Jason Kindrachuk, associate professor of medical microbiology and infectious diseases, Max Rady College of Medicine, Rady Faculty of Health Sciences; Canada Research Chair in molecular pathogenesis of emerging viruses; researcher, Children’s Hospital Research Institute of Manitoba 

Project: Characterization of long-term sequelae and immune signatures in Ebola virus disease survivors from 1976-2014 in the Democratic Republic of the Congo 

Grant: $100,000 (one year) 

Kindrachuk’s study will determine whether long-term health impacts following Ebola virus disease are conserved across geographic locations and what epidemiologic or biological factors might be linked to more severe complications and immune durability. The team will focus on disease survivors from multiple historic Ebola virus disease outbreaks within the Democratic Republic of the Congo and will also examine this through questionnaires and analysis of historical samples.  

Dr. Jonathan McGavock, professor of pediatrics and child health, Max Rady College of Medicine, Rady Faculty of Health Sciences; researcher, Children’s Hospital Research Institute of Manitoba 

Project: Honoring Ourselves and the Land – Reducing inequities in trail use for First Nations and Métis people in urban centres in Manitoba 

Grant: $1,266,075 (five years) 

With the help of Elders and Indigenous families, McGavock and his team will deliver and evaluate four main themed urban trail cultural events: 1) Full Moon ceremony walk/ride for girls, women and two-spirited people. 2) Land-based teachings with Elders/Knowledge Keepers. 3) Medicine teachings. The team will work with non-governmental organizations to plant gardens and/or traditional medicines in parks adjacent to the trails. 4) Youth-led teachings about local Indigenous cultures, languages and traditions. 

Dr. Donald Miller, professor of pharmacology and therapeutics, Max Rady College of Medicine, Rady Faculty of Health Sciences; researcher, Kleysen Institute for Advanced Medicine, Health Sciences Centre 

Project: Improving therapeutic outcomes in medulloblastoma through optimizing brain delivery of agents targeting inhibitors of apoptosis proteins 

Grant: $592,876 (four years) 

Miller’s medulloblastoma research will use a method his laboratory has developed and tested to selectively and reversibly open the blood-brain barrier to increase brain and tumour levels of chemotherapeutics and the XIAP sensitizing drugs to allow both radiation and chemotherapeutic agents to kill the tumour cells in the brain more effectively. Using peptides that target cadherin, the team will temporarily loosen the connections between the brain capillary endothelial cells to allow increased delivery of drugs and sensitizing agents to the brain tumour.  

Dr. Thomas Murooka, associate professor of immunology, Max Rady College of Medicine, Rady Faculty of Health Sciences 

Project: Role of mucosal neutrophils in driving HIV/HPV infection and disease progression 

Grant: $1,139,850 (five years) 

Murooka’s project will focus on specific bacteria linked to inflammatory disease in the lower female genital tract and identify the immune cells that further exacerbate this disease process. The team will use an animal disease model to better understand how this inflammatory process increases HIV and HPV infection, with the overall goal of defining why some individuals are more prone to sexually transmitted infections and to test drug candidates that can lower acquisition risk.  

Dr. Liam O’Neil, assistant professor of internal medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences 

Project: Cigarette smoking induced neutrophilic inflammation as a modifiable risk factor for Rheumatoid Arthritis in First Nations 

Grant: $100,000 (one year)  

O’Neil will investigate the way cigarette smoking interacts with the immune system, leading to rheumatoid arthritis. The team believes neutrophils, a common immune cell, are particularly prone to inflammation, leading to abnormal immune responses in people at high risk for rheumatoid arthritis development.  

Dr. Dake Qi, associate professor, College of Pharmacy, Rady Faculty of Health Sciences 

Project: TAAR1 in adipose tissue is a novel therapeutic target to combat atypical antipsychotics (AAPs)-induced metabolic dysfunction via downregulation of MIF 

Grant: $849,150 (five years) 

Qi’s project will investigate how trace amine-associated receptor (TAAR1) downregulates the release of macrophage migration inhibitory factor in fat cells and its impact on metabolic dysfunction induced by the classic atypical antipsychotics (AAP), olanzapine, by utilizing a combination of molecular and cellular biology techniques and physiological animal models. The team believes that TAAR1 agonists will improve the clinical psychiatric treatment with AAPs. 

Dr. Deanna Santer, assistant professor of immunology, Max Rady College of Medicine, Rady Faculty of Health Sciences 

Project: Role of type III interferons in regulating mucosal immunity in a healthy gut versus ulcerative colitis 

Grant: $967,725 (five years)  

Santer will study fresh gut tissues and blood collected from people with or without ulcerative colitis during routine clinic visits. The team will use a combination of their novel human biopsy culture model, 3D “mini-guts” and immune cells to find out exactly how type III interferons (IFN-L) promote gut health but also how IFN-L could dampen the overreactive immune cells causing symptoms.  

Dr. Jarret Woodmass, assistant professor of surgery, Max Rady College of Medicine, Rady Faculty of Health Sciences 

Project: Reverse total shoulder arthroplasty with and without subscapularis repair: Randomized controlled trial evaluating patient-reported and clinical outcomes 

Grant: $455,175 (five years)  

The aim of Woodmass’ study is to conduct a high-quality, randomized trial comparing outcomes of reverse total shoulder replacement (RTSA) with and without subscapularis repair. This ground-breaking study will provide evidence to support or negate the ongoing use of subscapularis repair in RTSA to optimize patient outcomes and manage scarce health-care resources. 

“Our researchers have demonstrated excellence by securing federal support for a diverse range of innovative health studies,” said UM Vice-President (Research and International) Dr. Mario Pinto.

“Many of our UM experts will be collaborating with community members to help our research have impact and provide solutions for society.”

Dr. Peter Nickerson, dean of the Rady Faculty of Health Sciences, also noted the involvement of community partners in many of the funded projects. “This is important because community members have valuable expertise to contribute,” he said.

Dr. Jonathan McGavock, professor of pediatrics and child health at the Max Rady College of Medicine in the Rady Faculty of Health Sciences, was a double recipient, landing two of the 10 grants to UM in the Spring 2023 round of funding.

McGavock, who is also a researcher with the Children’s Hospital Research Institute of Manitoba (CHRIM), has a key research interest in youth diabetes, with a particular focus on encouraging physical activity. The professor, who holds a PhD in exercise science, published a study last year demonstrating the cardiovascular health benefits associated with living near a multi-use activity trail.

He and his team have now received a grant of $1,453,500 to lead a five-year study of how Canadian cities can best implement urban trails that are fair for all citizens and generate the greatest possible cardiovascular health benefits. Seven cities, including Winnipeg, Brandon and Selkirk, are partners in the study.

“Our team will be working closely with city planners, and with organizations in all seven cities that support the use of trails, to create an optimal ‘recipe’ for trail creation that can inform the next wave of urban trails in Canadian cities,” McGavock said.  

The second grant to McGavock’s team is for $734,400 over four years. It will fund a randomized trial of a program for adolescents living with obesity. The program will support teens’ social, emotional and psychological needs as well as lifestyle changes, such as better sleep, daily activity and healthier eating.

“Very few treatments aimed at supporting a healthy lifestyle for adolescents with obesity incorporate skills to help regulate emotions and support positive mental health and quality of life,” McGavock said. 

“We want to determine if it’s feasible to deliver a treatment for teens living with obesity that includes emotional skills training.”

Here’s a look at the other CIHR-funded UM projects. More information on the studies and research teams is available here.

Dr. Jeremy Chopek, assistant professor, physiology and pathophysiology, Max Rady College of Medicine

Grant: $975,376 (five years)

Chopek’s study seeks to better understand how electrical spinal stimulation can not only improve motor function in people with spinal cord injury, but also improve the body’s autonomic functions, such as regulating heart rate and blood pressure. The long-term goal is to increase exercise capacity, reduce obesity and improve overall health in people living with spinal cord injury.

Dr. Sanjiv Dhingra, professor, physiology and pathophysiology, Max Rady College of Medicine; principal investigator, Institute of Cardiovascular Sciences, St. Boniface Hospital Research Centre

Grant: $1,027,780 (five years)

Dhingra will focus on mesenchymal stem cells (a type of multipotent cells that can differentiate into a variety of cell types) derived from bone marrow. Aiming to understand why, in treating heart disease, transplanted stem cells are rejected by the recipient, Dhingra’s team will experiment with modifying the cells to improve their survival in the heart.

Dr. Keith Fowke, professor, medical microbiology and infectious diseases, Max Rady College of Medicine

Grant: $100,000 (one year)

Partnering with community members in Nairobi, Kenya, Fowke’s team will study immune cells from Kenyan women who naturally clear the human papilloma virus (HPV) in the presence or absence of HIV co-infection. Because HPV causes cervical cancer, understanding how the immune system clears it naturally is an important step toward developing a vaccine to clear HPV infection.

Dr. Lauren Kelly, associate professor, pharmacology and therapeutics, Max Rady College of Medicine; researcher, CHRIM

Grant: $749,700 (three years)

Kelly will lead a randomized clinical trial of cannabidiol (CBD) alone versus CBD in combination with tetrahydrocannabinol (THC) as a treatment to reduce seizures in children and adults with drug-resistant epilepsy. Patient-centred organizations have partnered with researchers in guiding the trial, which will involve 90 participants across eight sites.

Dr. Lorrie Kirshenbaum, professor, physiology and pathophysiology, Max Rady College of Medicine; Canada Research Chair in molecular cardiology; director, Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre

Grant: $757,350 (five years)

Doxorubicin is an effective chemotherapy drug with the side effect of inducing heart failure in some cancer survivors. Kirshenbaum’s study will examine the apparent link between cancer patients’ disrupted body clocks, autophagy (the body’s process of “recycling” damaged cell parts to maintain cell quality), and the harmful effects of doxorubicin on the heart.

Dr. Deepak Louis, assistant professor, pediatrics and child health, Max Rady College of Medicine; researcher, CHRIM

Grant: $481,951 (four years, three months)

Louis will lead a three-province study of how the birth of a preterm baby affects siblings in the family. Parents of a preterm infant often experience stress, isolation, financial difficulties and mental health effects. Louis’s team will be the first to examine siblings’ risk for developing behavioural, socio-emotional, mental and physical health problems in childhood and adolescence.

Dr. Kristin Reynolds, associate professor, psychology, Faculty of Arts

Grant: $351,901 (four years)

Reynolds’ team will partner with community organizations in Manitoba, Saskatchewan, Ontario and British Columbia to implement and evaluate the CONNECT Program, a group telehealth mental health program for older adults. Working with the organizations, the researchers will assess the program’s effects on participants’ loneliness, social connection and mental health.

Dr. Roberta Woodgate, distinguished professor, College of Nursing; Canada Research Chair in child and family engagement in health research and healthcare; researcher, CHRIM

Grant: $100,000 (one year)

Woodgate’s mixed-methods study will focus on vaccine uptake within families. Her team aims to understand Manitoba childrearing families’ perspectives and decisions about vaccinating their family members against COVID-19 and influenza, with the goal of providing recommendations to promote vaccine uptake.

McGavock is an associate professor in the department of pediatrics, at the University of Manitoba, and a research scientist at the Children’s Hospital Research Institute of Manitoba. His research focuses on the prevention and management of type-2 diabetes in youth, with a particular focus on physical activity.

His research group focuses on a holistic approach, not just on body weight and blood sugars. From the standpoint of his research, McGavock says three things are key to creating a positive link between physical and mental health.

1. Do physical activity for your mind.
2. Find a friend to do it with.
3. Do it outside.

“In terms of mental health, if you were to ask someone who just spent half an hour on a treadmill or especially if they were outside walking through the woods, the first thing most people will report is lower stress and generally feeling better about themselves. A daily walk is something that allows you to get into your mind, think about things and reduce stress. It’s a way to reduce the noise, if you will,” McGavock says.

“Unfortunately, when most people decide to get physically active they do it for the wrong reasons. They’ll do it to look better: to lose weight or build muscles. But you don’t see those results every single day. If you’re doing exercise to lose weight, it could take up to six months to see a change, and even then it may not happen if you’re not exercising at an adequate level. On the other hand, you get mental health benefits no matter what, and you get it instantly. And I’d say if you do it outside, you get even more bang for your buck because there is something very peaceful and calming about being in green space.”

That covers his first and third point, but what about the second point, to be active with a friend? Why is that significant in the age of wearable devices like Fitbits, which track and encourage activities?

McGavock’s research shows that people who are active with a group of friends are more likely to sustain that lifestyle. Fitbits and other wearable devices, he says, are good for goal-setting people.

“If you’re someone who’s not a goal-setting person, having someone come to your office and say, ‘Hey, want to come for a walk with me?’ really resonates with an important part of our makeup as human beings, which is a sense of belonging. When people find that sense of belonging, they tend to be more resilient and have a better well-being.

“I don’t think a Fitbit is as powerful as a group of people who know that at lunch they are going to go for laps around campus because in that moment, in terms of mental health, they will be connecting with others, they’ll be outside, talking about their day and getting things off their chest. And on days when you’re not feeling great, the Fitbit is not going to motivate you to get out there, whereas your friend will.”